Trajectories of P2Y12 inhibitor adherence in patients with acute coronary syndromes.
Jungyeon MoonAya F OzakiAlice ChongManeesh SudJiming FangPeter C AustinDennis T KoCynthia A JackeviciusPublished in: Pharmacoepidemiology and drug safety (2023)
We identified distinct adherence trajectories for clopidogrel and ticagrelor post-ACS, with 3 out of 4 clopidogrel patients but only 2 out of 3 ticagrelor patients in the consistently adherent trajectory. Intensive interventions targeted to the period of steep adherence decline post-ACS, particularly for women and older persons initiating ticagrelor, and patients with atrial fibrillation on clopidogrel should be considered and investigated further.
Keyphrases
- acute coronary syndrome
- percutaneous coronary intervention
- antiplatelet therapy
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- st segment elevation myocardial infarction
- ejection fraction
- st elevation myocardial infarction
- physical activity
- peritoneal dialysis
- depressive symptoms
- prognostic factors
- coronary artery disease
- type diabetes
- drug delivery
- patient reported
- polycystic ovary syndrome
- high resolution
- skeletal muscle
- community dwelling