Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77-FGF21 pathway.

Palak AhujaXinyi BiChun Fai NgMargaret Chui Ling TseMiaojia HangBrian Pak Shing PangElsie Chit Yu IuWing Suen ChanXin Ci OoiAnqi SunOana Herlea-PanaZhixue LiuXiuying YangBaowei JiaoXin MaKelvin Ka Lok WuLeo Tsz On LeeKenneth King Yip ChengChi Wai Lee Chi Bun Chan

Published in: Hepatology (Baltimore, Md.) (2022)

Collectively, our data suggest that SBK1 is a regulator of the metabolic adaption against obesity through the Nur77-FGF21 pathway.

Keyphrases

insulin resistance
metabolic syndrome
type diabetes
tyrosine kinase
high fat diet induced
adipose tissue
high fat diet
skeletal muscle
polycystic ovary syndrome
weight loss
transcription factor
electronic health record
big data
physical activity
dna binding
protein kinase
machine learning
glycemic control