Integrated analysis of single-cell and bulk RNA sequencing data reveals a myeloid cell-related regulon predicting neoadjuvant immunotherapy response across cancers.
Hong LiuXiaoxian SimaBijing XiaoHaimiti GulizebaShen ZhaoTing ZhouYan HuangPublished in: Journal of translational medicine (2024)
The PPARG regulon is a predictor of ICI response. The myeloid cell map enables the identification of PPARG subclusters in public scRNA-seq datasets and provides a powerful discovery tool and resource value.
Keyphrases
- single cell
- rna seq
- high throughput
- dendritic cells
- acute myeloid leukemia
- bone marrow
- healthcare
- cell therapy
- electronic health record
- small molecule
- lymph node
- rectal cancer
- mental health
- stem cells
- big data
- mesenchymal stem cells
- squamous cell carcinoma
- immune response
- machine learning
- deep learning
- artificial intelligence
- data analysis