The role of autophagy in SIM mediated anti-inflammatory osteoclastogenesis through NLRP3 signaling pathway.

Yu-Ting ChengWenjun JinLin ZhengXiaolin HuangShanshan LuoWei HongJian LiaoBancha SamruajbenjakunChidchanok Leethanakul

Published in: Immunity, inflammation and disease (2024)

SIM may reduce autophagy secretion to attenuate LPS-induced osteoclastogenesis and the NLRP3 signaling pathway participates in this process, thus providing theoretical basis for the application of this drug in peri-implantitis.

Keyphrases

lps induced
signaling pathway
inflammatory response
pi k akt
anti inflammatory
induced apoptosis
epithelial mesenchymal transition
endoplasmic reticulum stress
cell death
nlrp inflammasome
oxidative stress