Tanshinone IIA Alleviates Traumatic Brain Injury by Reducing Ischemia‒Reperfusion via the miR-124-5p/FoxO1 Axis.
Wenbing SuMeifen LvDayu WangYinghong HeHui HanYu ZhangXiuying ZhangShaokun LvLiqing YaoPublished in: Mediators of inflammation (2024)
Tanshinone IIA alleviates ischemic-reperfusion brain injury by inhibiting neuroinflammation through the miR-124-5p/FoxO1 axis. This finding provides a theoretical basis for mechanistic research on cerebral ischemia-reperfusion injury.
Keyphrases
- cerebral ischemia
- subarachnoid hemorrhage
- ischemia reperfusion injury
- brain injury
- blood brain barrier
- signaling pathway
- transcription factor
- resting state
- pi k akt
- spinal cord injury
- white matter
- oxidative stress
- functional connectivity
- mouse model
- acute myocardial infarction
- heart failure
- lipopolysaccharide induced
- inflammatory response
- lps induced
- cognitive impairment
- left ventricular