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Intraindividual Change in Cognitive Function Among Adults With Systemic Lupus Erythematosus: A Markov Analysis Over 7 Years.

Stefan PereraRichard CookKer-Ai LeePatricia P KatzZahi Touma
Published in: ACR open rheumatology (2023)
Most individuals with SLE did not transition between states of high (Z score ≥ -1.5) or low (Z score < -1.5) cognition in a Markov analysis over a 7-year assessment period, highlighting a degree of relative stability in cognition over time. Increasing age and higher education levels were associated with greater likelihood of cognitive improvement. Greater self-reported SLE disease severity and depression were associated with cognitive decline.
Keyphrases
  • systemic lupus erythematosus
  • cognitive decline
  • mild cognitive impairment
  • disease activity
  • healthcare
  • white matter
  • physical activity
  • clinical evaluation