Combination of oligo-fractionated irradiation with nivolumab can induce immune modulation in gastric cancer.

Kousaku MimuraTakashi OgataPhuong H D NguyenSouvick RoyHassen KaredYate-Ching YuanMichael FehlingsYuya YoshimotoDaisaku YoshidaShotaro NakajimaHisashi SatoNozomu MachidaTakanobu YamadaYohei WatanabeTomoaki TamakiHirohito FujikawaYasuhiro InokuchiSuguru HayaseHiroyuki HanayamaZenichiro SazeHiroyuki KatohFumiaki TakahashiTakashi OshimaAjay GoelAlessandra NardinYoshiyuki SuzukiKoji Kono

Published in: Journal for immunotherapy of cancer (2024)

Oligo-fractionated irradiation induces an immune-modulating effect with potential antigen spreading and the combination of radiotherapy and nivolumab may be effective in a subset of patients with gastric cancer.

Keyphrases

radiation induced
early stage
radiation therapy
signaling pathway
locally advanced
brain metastases
small cell lung cancer
squamous cell carcinoma
human health
risk assessment