Senescent hepatic stellate cells caused by deoxycholic acid modulates malignant behavior of hepatocellular carcinoma.

Phuong Thao NguyenKeishi KannoQuoc Thang PhamYuka KikuchiMasaki KakimotoTomoki KobayashiYuichiro OtaniNobusuke KishikawaMutsumi MiyauchiKoji ArihiroMasanori ItoSusumu Tazuma

Published in: Journal of cancer research and clinical oncology (2020)

Our data suggest an important role of HSC senescence caused by DCA for the malignant biological behaviors of HCC via induction of SASP factors, particularly IL8 and TGFβ.

Keyphrases

induced apoptosis
cell cycle arrest
dna damage
electronic health record
transforming growth factor
endothelial cells
big data
oxidative stress
cell proliferation