Systemically delivered antibody-labeled magnetic iron oxide nanoparticles are less toxic than plain nanoparticles when activated by alternating magnetic fields.

Chun-Ting YangPreethi KorangathJackie StewartChen HuWei FuCordula GrüttnerSarah E BeckFeng-Huei LinRobert Ivkov

Published in: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (2021)

Results demonstrate that the MION coating affects biodistribution, which in turn determines off-target effects. Developments to improve heating capabilities of MIONs may be clinically irrelevant without better control of biodistribution.

Keyphrases

pet imaging
iron oxide nanoparticles
molecularly imprinted
sensitive detection
fluorescent probe
living cells
computed tomography
positron emission tomography
high resolution
simultaneous determination