The mechanism by which imeglimin inhibits gluconeogenesis in rat liver cells.

Guillaume VialFrédéric LamarcheCécile Cottet-RousselleSophie Hallakou-BozecAnne Laure Borel Eric Fontaine

Published in: Endocrinology, diabetes & metabolism (2021)

We conclude that imeglimin induces a kinetic constraint on the respiratory chain that does not affect its maximal activity. This kinetic constraint is offset by a decrease in the mitochondrial membrane potential, which induces a thermodynamic constraint on the ATPase responsible for a decrease in the ATP/ADP ratio.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
resistance training
signaling pathway
endoplasmic reticulum
climate change
aqueous solution