Intellectual functioning and behavioural features associated with mosaicism in fragile X syndrome.
Emma K BakerMarta ArponeSolange Aliaga VeraLesley BrethertonAlexandra UreClaudine M KraanMinh BuiLing LingDavid FrancisMatthew F HunterJustine ElliottCarolyn RogersMichael J FieldJonathan CohenLorena Santa MariaVictor FaundesBianca CurottoPaulina MoralesCesar TrigoIsabel SalasAngelica M AlliendeDavid J AmorDavid E GodlerPublished in: Journal of neurodevelopmental disorders (2019)
Males with FXS had significantly lower intellectual functioning than females with FXS. However, there were no significant differences in ASD features and maladaptive behaviours, after controlling for intellectual functioning, independent of the presence or absence of mosaicism. This suggests that interventions that primarily target cognitive abilities may in turn reduce the severity of maladaptive behaviours including ASD features in FXS.