Preferential uptake of SARS-CoV-2 by pericytes potentiates vascular damage and permeability in an organoid model of the microvasculature.
Abdullah Obaid KhanJasmeet S ReyatHarriet J HillJoshua H BourneMartina ColicchiaMaddy L NewbyJoel D AllenMax CrispinEsther YoudPaul G MurrayGraham TaylorZania StamatakiAlex G RichterAdam F CunninghamMatthew PughJulie RayesPublished in: Cardiovascular research (2022)
Endotheliitis is a serious complication of severe COVID-19 patients which remains poorly understood. We identify a pericyte mediated mechanism by which the vasculature becomes compromised, contributing to thrombotic complications, highlighting important avenues for the development of therapies.