Mitochondrial-nuclear coadaptation revealed through mtDNA replacements in Saccharomyces cerevisiae.

Tuc H M NguyenSargunvir SondhiAndrew ZieselSwati PaliwalHeather L Fiumera

Published in: BMC evolutionary biology (2020)

This study shows that natural variation in mitonuclear interactions contributes to fitness landscapes. Multiple examples of coadapted mitochondrial-nuclear genotypes suggest that selection for mitonuclear interactions may play a role in helping yeasts adapt to novel environments and promote coevolution.

Keyphrases

saccharomyces cerevisiae
oxidative stress
physical activity
body composition
mitochondrial dna
single cell
copy number
gene expression