Elevated nuclear TDP-43 induces constitutive exon skipping.
Rogger P Carmen-OrozcoWilliam TsaoYingzhi YeIrika R SinhaKoping ChangVickie T TrinhWilliam ChungKyra BowdenJuan C TroncosoSeth BlackshawLindsey R HayesShuying SunPhilip C WongJonathan P LingPublished in: Molecular neurodegeneration (2024)
Our findings emphasize the need for caution in interpreting TDP-43 overexpression data and stress the importance of controlling for exon skipping when generating models of TDP-43 proteinopathy.