Designing Porphyrinic Covalent Organic Frameworks for the Photodynamic Inactivation of Bacteria.
Jan HynekJaroslav ZelenkaJiří RathouskýPavel KubátTomáš RumlJan DemelKamil LangPublished in: ACS applied materials & interfaces (2018)
Microbial colonization of biomedical devices is a recognized complication contributing to healthcare-associated infections. One of the possible approaches to prevent surfaces from the biofilm formation is antimicrobial photodynamic inactivation based on the cytotoxic effect of singlet oxygen, O2(1Δg), a short-lived, highly oxidative species, produced by energy transfer between excited photosensitizers and molecular oxygen. We synthesized porphyrin-based covalent organic frameworks (COFs) by Schiff-base chemistry. These novel COFs have a three-dimensional, diamond-like structure. The detailed analysis of their photophysical and photochemical properties shows that the COFs effectively produce O2(1Δg) under visible light irradiation, and especially three-dimensional structures have strong antibacterial effects toward Pseudomonas aeruginosa and Enterococcus faecalis biofilms. The COFs exhibit high photostability and broad spectral efficiency. Hence, the porphyrinic COFs are suitable candidates for the design of antibacterial coating for indoor applications.
Keyphrases
- biofilm formation
- energy transfer
- pseudomonas aeruginosa
- metal organic framework
- staphylococcus aureus
- candida albicans
- healthcare
- visible light
- escherichia coli
- quantum dots
- cystic fibrosis
- photodynamic therapy
- cancer therapy
- acinetobacter baumannii
- silver nanoparticles
- microbial community
- anti inflammatory
- high resolution
- air pollution
- water soluble
- particulate matter
- magnetic resonance imaging
- essential oil
- multidrug resistant
- radiation induced
- risk assessment
- magnetic resonance
- drug discovery
- drinking water