Performance characteristics of screening strategies to identify Lynch syndrome in women with ovarian cancer.
Soyoun Rachel KimAlicia ToneRaymond H KimMatthew CesariBlaise A ClarkeLua EirikssonTae L HartMelyssa AronsonSpring HolterAlice LytwynManjula MagantiLeslie OldfieldSteven GallingerMarcus Q BernardiniAmit M OzaBojana DjordjevicJordan Lerner- EllisEmily Van de LaarDanielle VicusTrevor J PughAaron PollettSarah E FergusonPublished in: Cancer (2020)
Sequential IHC (with MLH1 promoter methylation analysis) followed by MSI was found to be most sensitive. However, IHC with MLH1 promoter methylation analysis also performed well and is likely more cost-effective and efficient in the clinical setting. The pretest probability of LS is high in patients with MMR deficiency and warrants universal screening for LS.