Interpreting the Complex Landscape of Immune-Tumor Interface.

Predictive biomarkers for immune therapy must address a complex interface between the immune system and triple-negative breast cancer and still be technically reliable for diagnostic use. Two recent articles describe the assessment of spatial heterogeneity using digital methods that promise to improve the quantification of immune infiltrate or molecular targets.See related articles by Bai et al., p. 5557 and Carter et al., p. 5628.