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Perfusate hemoglobin during normothermic liver machine perfusion as biomarker of early allograft dysfunction: A pilot study.

Akinori MaedaGraham StarkeySofia SpanoAnis ChabaGlenn EastwoodOsamu YoshinoMarcos Vinicius PeriniMichael FinkRinaldo BellomoRobert Jones
Published in: Artificial organs (2024)
Perfusate hemoglobin levels decreased during NMP, and lower perfusate hemoglobin levels were associated with a higher incidence of EAD and higher levels of liver injury markers. Maintaining higher hemoglobin levels during NMP may help reduce ischemia-reperfusion injury and prevent or attenuate EAD. Larger prospective studies are needed to validate the findings of this pilot study.
Keyphrases
  • liver injury
  • drug induced
  • ischemia reperfusion injury
  • oxidative stress
  • red blood cell
  • magnetic resonance imaging
  • risk factors
  • computed tomography
  • magnetic resonance
  • deep learning