Simple Aggregation-Induced Emission-Based Multifunctional Fluorescent Dots for Cancer Therapy In Vitro.
Xueran LinJunhao ZhaoWei HuangHongxing LiuPengju FengFang YangTianfeng ChenPublished in: Chemistry, an Asian journal (2019)
Multifunctional nanoparticles were simply synthesized by mixing a TICT+AIE featured molecule (TPAPP-CHO) with PBS solution. The fluorescent (FL) dots entered the cells via energy-related endocytosis and were located in lysosome emitting green FL. This indicated that the nanoparticles were dissociated in the lysosome. Moreover, the synthesized nanoparticles (NPs) demonstrate potent cytotoxicity against human U87 glioblastoma cells by inducing cell apoptosis via triggering intracellular ROS overproduction.
Keyphrases
- fluorescent probe
- living cells
- cancer therapy
- induced apoptosis
- drug delivery
- cell cycle arrest
- quantum dots
- cell death
- endothelial cells
- endoplasmic reticulum stress
- reactive oxygen species
- single molecule
- signaling pathway
- dna damage
- walled carbon nanotubes
- molecularly imprinted
- label free
- metal organic framework
- induced pluripotent stem cells