Obesity impairs leukocyte-endothelium cell interactions and oxidative stress in humans.
Sandra López-DomènechCelia BañulsNoelia Díaz-MoralesIrene Escribano-LópezCarlos MorillasSilvia VesesSamuel OrdenÁngeles ÁlvarezVíctor M VíctorAntonio Hernández-MijaresMilagros RochaPublished in: European journal of clinical investigation (2018)
Our findings reveal that endothelial dysfunction markers are altered in human obesity and are associated with proinflammatory cytokines and increased oxidative stress parameters.
Keyphrases
- oxidative stress
- insulin resistance
- metabolic syndrome
- weight loss
- single cell
- high fat diet induced
- type diabetes
- endothelial cells
- weight gain
- dna damage
- ischemia reperfusion injury
- diabetic rats
- induced apoptosis
- nitric oxide
- cell therapy
- induced pluripotent stem cells
- adipose tissue
- gene expression
- dna methylation
- signaling pathway
- mesenchymal stem cells
- bone marrow
- endoplasmic reticulum stress