Distribution and hormonal characterization of primary murine L cells throughout the gastrointestinal tract.

Kazuyo SuzukiKanako IwasakiYuki MurataNorio HaradaShunsuke YamaneAkihiro HamasakiKimitaka ShibueErina JooAkiko SankodaYuta FujiwaraYoshitaka HayashiNobuya Inagaki

Published in: Journal of diabetes investigation (2017)

L cells show different numbers and characteristics throughout the gut, and they express different mRNA levels of transcription factors and gastrointestinal hormones. These results contribute to the therapeutic application of promoting GLP-1 release from L cells for the treatment of type 2 diabetes.

Keyphrases

induced apoptosis
cell cycle arrest
transcription factor
endoplasmic reticulum stress
type diabetes
cell death
metabolic syndrome