Novel insights into the synergistic effects of selenium nanoparticles and metformin treatment of letrozole - induced polycystic ovarian syndrome: targeting PI3K/Akt signalling pathway, redox status and mitochondrial dysfunction in ovarian tissue.
Hanem M RabahDarin A MohamedReham A MariahSarah Ragab Abd El-KhalikHaidy A KhattabNorhan A AbuoHashishAmal M AbdelsattarMohamed A RaslanEman E FarghalAmira Kamel EltokhyPublished in: Redox report : communications in free radical research (2023)
HighlightsThe strong relationship between obesity, insulin resistance, and polycystic ovarian syndrome.Disturbance of the PI3K/Akt signaling pathway is involved in the progression of polycystic ovary syndrome-insulin resistance (PCOS-IR).In PCOS-IR rats, combined SeNPs and metformin therapy considerably alleviated IR by acting on the PI3K/Akt signaling pathway.The combination of SeNPs and metformin clearly repaired ovarian polycystic pathogenesis and improved hormonal imbalance in PCOS-IR rats.
Keyphrases
- polycystic ovary syndrome
- insulin resistance
- pi k akt
- signaling pathway
- adipose tissue
- metabolic syndrome
- high fat diet
- skeletal muscle
- high fat diet induced
- type diabetes
- cell cycle arrest
- cell proliferation
- induced apoptosis
- epithelial mesenchymal transition
- diabetic rats
- physical activity
- drug delivery
- body mass index
- mesenchymal stem cells
- weight gain
- cell therapy
- endothelial cells