Unraveling the Genetic Susceptibility of Irritable Bowel Syndrome: integrative genome-wide analyses in 845,492 individuals: a diagnostic study.

Wentao HuangLijun ZhangYuying MaShiyi YuYanlin LyuShuangshuang TongJiaxuan WangRui JiangMeijun MengYanjun WuRuibang LuoXinqi QiuWeihong ShaHao Chen

Published in: International journal of surgery (London, England) (2024)

We identified seven novel risk loci for IBS and highlight the substantial influence on genetic risk harboured. Our findings offer novel insights into aetiology and phenotypic association of IBS and lay the foundation for therapeutic targets and interventional strategies.

Keyphrases

irritable bowel syndrome
genome wide
dna methylation
copy number