Decoding Early Psychoses: Unraveling Stable Microstructural Features Associated with Psychopathology Across Independent Cohorts.

Haley R WangZhen-Qi LiuHajer NakuaCatherine E HegartyMelanie Blair ThiesPooja K PatelCharles H SchleiferThomas P BoeckRachel A McKinneyDanielle CurrinLogan LeathemPamela DeRosseCarrie E BeardenBratislav MisicKatherine H Karlsgodt

Published in: bioRxiv : the preprint server for biology (2024)

This data-driven transdiagnostic approach revealed a stable and replicable neurobiological signature of microstructural WM alterations in EP, across diagnoses and datasets, showing a strong covariance of these alterations with a unique profile of negative and somatic symptoms. This finding suggests the clinical utility of applying data-driven approaches to reveal symptom domains that share neurobiological underpinnings.

Keyphrases

white matter
single cell
rna seq
genome wide
copy number
multiple sclerosis
sleep quality
depressive symptoms
anorexia nervosa