Association of Tumor Mutational Burden and Microsatellite Instability With Response and Outcomes in Patients With Urothelial Carcinoma Treated With Immune Checkpoint Inhibitor.
Dimitra Rafailia BakaloudiRafee TalukderDimitrios MakrakisLeonidas DiamantopoulosThomas EnrightJacob B LearyUbenthira PatgunarajahVinay M ThomasUmang SwamiNeeraj AgarwalTanya JindalVadim S KoshkinJason R BrownPedro BarataJure MurgićMarija MiletićJeffrey JohnsonYousef ZakhariaGavin HuiAlexandra DrakakiIgnacio DuranLucia A BuznegoRafael M BarreraDavid M CastañedaMacarena Rey-CárdenasDaniel CastellanoCharles B NguyenJoseph J ParkAjjai AlvaRana R McKayTyler F StewartIlana B EpsteinJoaquim BellmuntJonathan L WrightShilpa GuptaPetros GrivasAli Raza KhakiPublished in: Clinical genitourinary cancer (2024)
Although not reaching statistical significance in several subsets, patients with high TMB and MSI-H had numerically longer OS with ICI, especially with mAV. Further validation is needed.