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A pharmacological challenge predicts reversible rectal sensorimotor dysfunctions in women with fecal incontinence.

M SharmaK FeuerhakA R ZinsmeisterAdil E Bharucha
Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)
The effects of atropine and clonidine on rectal distensibility and sensation were significantly correlated. A preserved response to atropine suggests that reduced rectal distensibility is partly reversible, mediated by cholinergic mechanisms, and may predict the response to clonidine, providing a pharmacological challenge.
Keyphrases
  • rectal cancer
  • functional connectivity