Placental transfer of doravirine, a recent HIV-1 NNRTI in the ex vivo human cotyledon perfusion model.
Minh Patrick LêLucile PencoléGilles PeytavinFlorian Bouchet-CrivatLaurent MandelbrotPublished in: The Journal of antimicrobial chemotherapy (2021)
Doravirine both crosses and accumulates in the placenta. This may be useful as pre/post-exposure prophylaxis to reduce the risk of vertical HIV transmission but carries the potential for fetal toxicities. Further investigation is required to determine the safety and efficacy of this new antiretroviral agent in pregnancy.
Keyphrases
- hiv positive
- hiv infected
- antiretroviral therapy
- human immunodeficiency virus
- hiv aids
- hiv testing
- men who have sex with men
- hepatitis c virus
- hiv infected patients
- south africa
- endothelial cells
- preterm birth
- computed tomography
- magnetic resonance imaging
- induced pluripotent stem cells
- pregnant women
- risk assessment