Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events.
George AllenBenjamin WeissOlesya O PanasenkoSusanne HuchZoltan VillanyiBenjamin AlbertDaniel DilgMarina ZagattiPaul SchaughencySusan E LiaoJeff CordenChristine PolteDavid ShoreZoya IgnatovaVicent PelechanoMartine A CollartPublished in: Genome biology (2023)
Our results reveal that mRNA solubility defines the dynamics of co-translation events and is oppositely regulated by Not1 and Not4, a mechanism that we additionally determine may already be set by Not1 promoter association in the nucleus.