Synthetic MRI and MR Fingerprinting-Derived Relaxometry of Antenatal Human Brainstem Myelination: A Postmortem-Based Quantitative Imaging Study.
Victor U SchmidbauerIntesar-Victoria Malla HouechJakob MalikMartin L WatzenboeckRebecca MittermaierPatric KienastChristina HaberlIvana PogledicChristian MitterGregor O DovjakAstrid KrauskopfFlorian PrayerMarlene StümpflenTim DorritkeNikolai A GantnerJulia BinderDieter BettelheimHerbert KissChristine HaberlerEllen GelpíDaniela PrayerGregor J KasprianPublished in: AJNR. American journal of neuroradiology (2024)
There is a good-to-excellent consistency between postmortem Synthetic MR imaging and MR fingerprinting myelin quantifications in fetal brains older than 15 + 1 gestational age. The strong correlations between quantitative myelin metrics and gestational age indicate the potential of quantitative MR imaging to identify delayed or abnormal states of myelination at prenatal stages of cerebral development.
Keyphrases
- gestational age
- contrast enhanced
- preterm birth
- birth weight
- high resolution
- magnetic resonance imaging
- magnetic resonance
- pregnant women
- computed tomography
- endothelial cells
- diffusion weighted imaging
- white matter
- subarachnoid hemorrhage
- weight gain
- photodynamic therapy
- induced pluripotent stem cells
- mass spectrometry
- body mass index
- climate change
- blood brain barrier
- human health
- fluorescence imaging
- weight loss