Chemical reversion of age-related oocyte dysfunction fails to enhance embryo development in a bovine model of postovulatory aging.

Ana Filipa FerreiraJuliana Machado-SimõesInês MonizMaria SoaresAlexandra CarvalhoPatrícia DinizJoão Ramalho-SantosAna Paula SousaLuís Lopes-da-CostaTeresa Almeida-Santos

Published in: Journal of assisted reproduction and genetics (2024)

Resveratrol and phloretin can both revert the age-related oxidative stress and mitochondrial dysfunction during postovulatory aging but were insufficient to enhance embryo developmental rates under our experimental conditions.

Keyphrases

oxidative stress
pregnancy outcomes
dna damage
ischemia reperfusion injury
diabetic rats
induced apoptosis
pregnant women
signaling pathway
endoplasmic reticulum stress