CD73-Mediated Immunosuppression Is Linked to a Specific Fibroblast Population That Paves the Way for New Therapy in Breast Cancer.

Ilaria MagagnaNicolas GourdinYann KiefferMonika LicajRana MhaidlyPascale AndreAriane MorelAnne-Vincent SalomonCarine PaturelFatima Mechta-Grigoriou

Published in: Cancers (2021)

Our data support the potential clinical benefit of using both anti-CD73 and immune-checkpoint inhibitors in breast cancer patients for inhibiting CAF-S1-mediated immunosuppression and enhancing anti-tumor immune response.

Keyphrases

immune response
signaling pathway
nk cells
big data
stem cells
machine learning
inflammatory response
human health
artificial intelligence