Autophagy and salivary gland cancer: A putative target for salivary gland tumors.
Evangelos KoustasPanagiotis SarantisMargarita TheodorakidouMichalis V KaramouzisStamatios TheocharisPublished in: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (2020)
Salivary gland carcinomas are a group of heterogeneous tumors of different histological subtypes, presenting relatively low incidence but the entire variable of types. Although novel treatment options for salivary gland carcinomas patients' outcomes have improved, the treatment of this type of cancer is still not standardized. In addition, a significant number of patients, with a lack of optimal treatment strategies, have reduced survival. In the last two decades, a plethora of evidence pointed to the importance of autophagy, an essential catabolic process of cytoplasmatic component digestion, in cancer. In vitro and in vivo studies highlight the importance of autophagy in salivary gland carcinomas development as a tumor suppressor or promoter mechanism. Despite the potential of autophagy in salivary gland carcinomas development, no therapies are currently available that specifically focus on autophagy modulation in salivary gland carcinomas. In this review, we summarize current knowledge and clinical trials in regard to the interplay between autophagy and the development of salivary gland carcinomas. Autophagy manipulation may be a putative therapeutic strategy for salivary gland carcinomas patients.
Keyphrases
- cell death
- endoplasmic reticulum stress
- high grade
- signaling pathway
- oxidative stress
- end stage renal disease
- clinical trial
- papillary thyroid
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- healthcare
- young adults
- risk factors
- squamous cell carcinoma
- open label
- metabolic syndrome
- study protocol
- weight loss
- combination therapy
- climate change
- free survival
- smoking cessation