CDK5RAP3 inhibits angiogenesis in gastric neuroendocrine carcinoma by modulating AKT/HIF-1α/VEGFA signaling.

Jian-Xian LinXiong-Feng WengXin-Sheng XieNing-Zi LianSheng-Liang QiuJia-Bin WangJun LuQi-Yue ChenLong-Long CaoMi LinRu-Hong TuYing-Hong YangSi-Jia LiuMin HuYi-Ke LinChang-Ming HuangChao-Hui ZhengPing LiJian-Wei Xie

Published in: Cancer cell international (2019)

This study demonstrated that CDK5RAP3 inhibits angiogenesis by downregulating AKT/HIF-1α/VEGFA signaling in GNEC and improves patient prognosis, suggesting that CDK5RAP3 could be a potential therapeutic target for GNEC.

Keyphrases

endothelial cells
cell cycle
signaling pathway
cell proliferation
vascular endothelial growth factor
case report
wound healing
risk assessment
human health