Extracellular DNA Containing (dG)n Motifs Penetrates into MCF7 Breast Cancer Cells, Induces the Adaptive Response, and Can Be Expressed.
Ekaterina A KozhinaElizaveta S ErshovaNatalya A OkorokovaVladimir P VeikoElena M MalinovskayaVasilina A SergeevaMarina S KonkovaSerguey I KutsevNataly N VeikoSvetlana V KostyukPublished in: Oxidative medicine and cellular longevity (2019)
GC-rich DNA fragments containing dGn motifs that are inclined to oxidation penetrate into MCF7 cancer cells, stimulate the adaptive response, and can be expressed. This property of GC-rich cell-free DNA should be considered and/or could potentially be used in therapy of tumors.