New Jatrophane-Type Diterpenoids from Euphorbia kansui as Potential MDR Reversal Agents.
Qiong ZhengNing-Yu ChenSi-Qing LouQian-Qing LiuYi-Tong LuoDong-E LiangZha-Jun ZhanLie-Feng MaPublished in: Chemistry & biodiversity (2022)
A serial jatrophane-type diterpenoids, comprised with three undescribed compounds kanesulones C-E (1-3) and four known ones (4-7), were obtained from the roots of Euphorbia kansui. The structures of compounds 1-3 were elucidated by detailed interpretation of their spectroscopic data, especially 2D-NMR and HR-ESI-MS, the absolute configuration of 1 was revealed by single crystal X-ray diffraction. These isolates were assayed for their multidrug resistance reversing activities on human breast adenocarcinoma cell line MCF-7/ADR. Compound 1 possessed potential as low toxic MDR modulator that could promote the efficacy of anticancer drug adriamycin ca. 85-fold at 5 μM, as 12 times stronger than the positive drug verapamil.
Keyphrases
- high resolution
- ms ms
- adverse drug
- multidrug resistant
- endothelial cells
- multiple sclerosis
- magnetic resonance
- mass spectrometry
- human health
- squamous cell carcinoma
- electronic health record
- molecular docking
- breast cancer cells
- emergency department
- drug induced
- induced pluripotent stem cells
- risk assessment
- magnetic resonance imaging
- electron microscopy
- protein kinase
- deep learning