Impact of PNPLA3 and TM6SF2 polymorphisms on the prognosis of patients with MASLD and type 2 diabetes mellitus.

Natália Coelho Lavrado Gil Fernando Salles Claudia Regina Lopes Cardoso Paulo Henrique Condeixa de França Maria Fernanda Di Guimarães Gonçalves Melo Nathalie Carvalho Leite Cristiane Alves Villela Nogueira

Published in: Liver international : official journal of the International Association for the Study of the Liver (2024)

In T2DM, PNPLA3 and TM6SF2 polymorphisms, individually and additively, impact MASLD severity, with an increased risk of cirrhosis and its complications.

Keyphrases

glycemic control
risk factors
type diabetes
cardiovascular disease
metabolic syndrome
skeletal muscle