Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning.

Alexander NeumannOlena OhleiFahri KüçükaliIsabelle J BosJigyasha TimsinaStephanie VosDmitry ProkopenkoBetty M TijmsUlf AndreassonKaj BlennowRik VandenberghePhilip ScheltensCharlotte E TeunissenSebastiaan EngelborghsGiovanni B FrisoniOliver BlinJill C RichardsonRégis BordetAlberto LleóDaniel AlcoleaJulius PoppThomas W MarshPriyanka GorijalaChristopher ClarkGwendoline PeyratoutPablo Martinez-LageMikel TaintaRichard J B DobsonCristina Legido-QuigleyChristine Van BroeckhovenRudolph E TanziMara Ten KateChristina M LillFrederik BarkhofCarlos CruchagaSimon LovestoneJohannes StrefferHenrik ZetterbergPieter Jelle VisserKristel SleegersLars Bertramnull null

Published in: Genome medicine (2023)

These results suggest that pathway and sex-specific analyses can improve our understanding of AD genetics and may contribute to precision medicine.

Keyphrases

cognitive decline
data analysis
prefrontal cortex
genome wide association study