IL-33 polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort.
Paul C SchröderVera I CasacaSabina IlliMaximilian SchieckSven MichelAndreas BöckCaroline RoduitRemo FreiAnna LluisJon GenuneitPetra PfefferleMarjut RoponenJuliane WeberCharlotte Braun-FahrländerJosef RiedlerRoger LauenerDominique Angèle VuittonJean-Charles DalphinJuha PekkanenErika von MutiusMichael KabeschBianca Schaubnull nullPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2016)
IL-33-polymorphisms rs928413 and rs1342326 may account for an increased risk of hay fever with the age of 6 years. Lower Tregs and increased SOCS3 in combined heterozygotes and minor allele homozygotes may be relevant for hay fever development, pointing towards dysbalanced immune regulation and insufficient control of allergic inflammation.