Effect of Anti-S100A4 Monoclonal Antibody Treatment on Experimental Skin Fibrosis and Systemic Sclerosis-Specific Transcriptional Signatures in Human Skin.

Thuong Trinh-MinhAndrea-Hermina GyörfiMichal TomcikCuong Tran-ManhXiang ZhouNicholas DickelBilgesu Safak TümerdemAlexander KreuterSven-Niklas BurmannSigne Vedel BorchertRizwan Iqbal HussainJonas HallénJörg KlingelhöferMeik KunzJörg H W Distler

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

Inhibition of S100A4 confers dual targeting of inflammatory and fibrotic pathways in complementary mouse models of fibrosis and in SSc skin. These effects support the further development of anti-S100A4 mAbs as disease-modifying targeted therapies for SSc.

Keyphrases

systemic sclerosis
monoclonal antibody
interstitial lung disease
soft tissue
mouse model
wound healing
oxidative stress
gene expression
transcription factor
liver fibrosis
rheumatoid arthritis
genome wide
idiopathic pulmonary fibrosis
heat shock
drug delivery
heat stress