Recent Advances in Crosslinked Nanogel for Multimodal Imaging and Cancer Therapy.
Wen ZhouGuangzhao YangXiaoyue NiShanchao DiaoChen XieQuli FanPublished in: Polymers (2020)
Nanomaterials have been widely applied in the field of cancer imaging and therapy. However, conventional nanoparticles including micelles and liposomes may suffer the issue of dissociation in the circulation. In contrast, crosslinked nanogels the structures of which are covalently crosslinked have better physiological stability than micelles and liposomes, making them more suitable for cancer theranostics. In this review, we summarize recent advances in crosslinked nanogels for cancer imaging and therapy. The applications of nanogels in drug and gene delivery as well as development of novel cancer therapeutic methods are first introduced, followed by the introduction of applications in optical and multimodal imaging, and imaging-guided cancer therapy. The conclusion and future direction in this field are discussed at the end of this review.
Keyphrases
- high resolution
- cancer therapy
- drug delivery
- papillary thyroid
- squamous cell
- hyaluronic acid
- squamous cell carcinoma
- drug release
- magnetic resonance imaging
- stem cells
- fluorescence imaging
- pain management
- lymph node metastasis
- mass spectrometry
- childhood cancer
- current status
- bone marrow
- adverse drug
- walled carbon nanotubes