A physics-based machine learning model called MLRNet has been developed to construct the high-accuracy two-body intermolecular potential energy surface (IPES). The outputs of the neural network are integrated into the physically realistic Morse/long-range (MLR) function, which ensures that the MLRNet has meaningful extrapolation at both short and long ranges and solves the asymptotic problem in common neural network potential (NNP) models. The neural network representation of the MLR parameters is more flexible and more efficient than the polynomial expansion in the conventional mdMLR model, especially for systems containing nonrigid monomer(s). The present work illustrates the basic framework of the current MLRNet model, including (i) how to combine the physically meaningful MLR function with different possible NN structures, (ii) the preservation of permutation symmetry, and (iii) the predetermination of the long-range function u LR . We choose two realistic systems to demonstrate the performance of MLRNet: the three-dimensional IPES of CO 2 -He including the CO 2 antisymmetric vibration Q 3 and the six-dimensional IPES of the H 2 O-Ar system. In both cases, the fitting errors of the MLRNet are several times smaller than those of the conventional mdMLR model. Both short-range and long-range extrapolation tests were performed to illustrate the extrapolation ability of the MLRNet and its damping function version. Moreover, for the 6-D H 2 O-Ar system, the MLRNet only needs 1596 trainable parameters, which is almost equal to the number needed for the 5-D mdMLR model (1509) and half that needed for the PIP-NN model (3501) within similar accuracy, which illustrates the model efficiency in high-dimensional IPES fitting.