Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma.

Shumei Song Qiongrong ChenYuan LiGuang LeiAiling ScottLongfei HuoCordelia Y LiJeannelyn Santiano EstrellaArlene CorreaMelissa Pool PizziLang MaJiankang JinBin LiuYing WangLianchun XiaoWayne L HofstetterJeffrey H LeeBrian WestonManoop BhutaniNamita ShanbhagRandy L JohnsonBoyi GanShaozhong WeiJaffer A Ajani

Published in: Gut (2021)

Our preclinical and clinical data suggest that AT-101 overcomes resistance by targeting CSCs pathways suggesting a novel mechanism of action of AT101 in patients with GEC.

Keyphrases

cancer stem cells
cell therapy
electronic health record
big data
machine learning
bone marrow