The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis.

Meritxell PerramónSilvia CarvajalVedrana ReichenbachGuillermo Fernández-VaroLoreto BoixLaura Macias-MuñozSilvia MelgarJordi BruixShlomo MelmedSantiago LamasWladimiro Jiménez

Published in: Liver international : official journal of the International Association for the Study of the Liver (2022)

Pttg1/Dlk1 are selectively overexpressed in the cirrhotic liver and participate in ECM turnover regulation. Pttg1 disruption decreases Dlk1 transcription and attenuates collagen deposition. PTTG1/DLK1 signalling is a novel pathway for targeting the progression of liver fibrosis.

Keyphrases

liver fibrosis
genome wide
transcription factor
copy number
cancer therapy
bone mineral density
extracellular matrix
dna methylation
growth hormone