Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major.
Jua IwasakiDonald D LorimerMirella Vivoli-VegaEmily A KibbleChristopher S PeacockJan AbendrothStephen J MayclinDavid M DranowPhillip G PierceDavid FoxMaria LewisNicole M BzdylSofie S KristensenTimothy J J InglisCharlene M KahlerCharles S BondAnja HasenkopfFlorian SeufertJens SchmitzLaura E MarshallAndrew E ScottIsobel H NorvillePeter J MylerUlrike HolzgrabeNicholas J HarmerMitali Sarkar-TysonPublished in: The Journal of antimicrobial chemotherapy (2022)
These results indicate that Mip is a novel antivirulence target that can be inhibited using small-molecule compounds that prove to be promising broad-spectrum drug candidates in vitro. Further optimization of compounds is required for in vivo evaluation and future clinical applications.