COVID-19 associated brain/spinal cord lesions and leptomeningeal enhancement: A meta-analysis of the relationship to CSF SARS-CoV-2.
Ariane LewisRajan JainJennifer FronteraDimitris G PlacantonakisSteven GalettaLaura BalcerKara R MelmedPublished in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2021)
The presence of CNS hyperintense lesions or leptomeningeal enhancement on neuroimaging from patients with COVID-19 is associated with increased likelihood of a positive CSF SARS-CoV-2 PCR. However, a positive CSF SARS-CoV-2 PCR is uncommon in patients with these neuroimaging findings, suggesting they are often related to other etiologies, such as inflammation, hypoxia, or ischemia.