Effects of dapagliflozin on urinary metabolites in people with type 2 diabetes.

Skander MulderHiddo J Lambers HeerspinkManjula DarshiJiwan J KimGozewijn D LavermanKumar SharmaMichelle J Pena

Published in: Diabetes, obesity & metabolism (2019)

Dapagliflozin significantly increased a panel of urinary metabolites previously linked to mitochondrial metabolism. These data support the hypothesis that SGLT2 inhibitors improve mitochondrial function, and improvements in mitochondrial function could be a mechanism for kidney protection. Future studies with longer treatment duration and clinical outcomes are needed to confirm the clinical impact of these findings.

Keyphrases

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oxidative stress
electronic health record
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machine learning
case control
smoking cessation
deep learning