Infliximab therapy together with tyrosine kinase inhibition targets leukemic stem cells in chronic myeloid leukemia.

Oliver HerrmannMaja Kim KuepperMarlena BütowIvan G CostaIris AppelmannFabian BeierTom LueddeTill BraunschweigSteffen KoschmiederTim H BrümmendorfMirle Schemionek-Reinders

Published in: BMC cancer (2019)

TNFα signaling is induced in CML stem cells, and anti-inflammatory therapy enhances TKI-induced decline of LSC, confirming that successful targeting of persisting CML stem cells can be enhanced by addressing their malignant microenvironment simultaneously.

Keyphrases

stem cells
chronic myeloid leukemia
tyrosine kinase
high glucose
epidermal growth factor receptor
cell therapy
diabetic rats
anti inflammatory
rheumatoid arthritis
endothelial cells
drug induced
cancer therapy
ulcerative colitis
stress induced