Evaluation of inherited germline mutations in cancer susceptibility genes among pancreatic cancer patients: a single-center study.
Francesca TavanoDomenica GioffredaAndrea FontanaOrazio PalmieriAnnamaria GentileTiziana LatianoAnna LatianoTiziana Pia LatianoMatteo ScaramuzziEvaristo MaielloFrancesca BazzocchiFrancesco PerriPublished in: Molecular medicine (Cambridge, Mass.) (2023)
This study confirmed the potential remarkable contribution of BRCA2 in assessing the presence of PanC. Overall our findings supported the recommendation of offering the germline testing to all the PanC patients with the intent to reduce the number of underdiagnosed carriers of mutations in predisposition genes, and not to preclude their relatives from the opportunity to benefit from surveillance programs.
Keyphrases
- end stage renal disease
- public health
- genome wide
- newly diagnosed
- chronic kidney disease
- ejection fraction
- dna repair
- papillary thyroid
- peritoneal dialysis
- prognostic factors
- bioinformatics analysis
- genome wide identification
- gene expression
- squamous cell
- risk assessment
- patient reported outcomes
- dna methylation
- oxidative stress
- lymph node metastasis
- human health