Non-genetic cell-surface modification with a self-assembling molecular glue.
Hayase HakariyaIppei TakashimaMisao TakemotoNaotaka NodaShin-Ichi SatoMotonari UesugiPublished in: Chemical communications (Cambridge, England) (2021)
This report describes the development of a non-genetic cell-surface modification method, in which a self-assembling small molecule is combined with Halo-tag proteins. Cell-surface functionalization with cancer-linked extracellular proteins led to enhanced cell motility, angiogenesis, and immune shielding of the cells, paving the way for translational opportunities for cell therapy.
Keyphrases
- cell surface
- cell therapy
- small molecule
- stem cells
- induced apoptosis
- mesenchymal stem cells
- genome wide
- papillary thyroid
- cell cycle arrest
- copy number
- endothelial cells
- squamous cell
- single cell
- biofilm formation
- protein protein
- vascular endothelial growth factor
- dna methylation
- squamous cell carcinoma
- cell death
- lymph node metastasis
- pseudomonas aeruginosa
- single molecule
- staphylococcus aureus
- gene expression
- cell proliferation
- escherichia coli
- childhood cancer
- candida albicans