The utility of claudin-4 versus MOC-31 and Ber-EP4 in the diagnosis of metastatic carcinoma in cytology specimens.

Saleh NajjarQiong GanJohn StewartNour Sneige

Published in: Cancer cytopathology (2022)

Claudin-4 can be used as a single marker for carcinoma with high sensitivity and superior specificity compared with MOC-31 and Ber-EP4. Mesothelial lineage can be ruled out when claudin-4 is positive. In equivocal cytology samples with few scattered cells of interest, a panel of claudin-4 and Ber-EP4 results in the highest combined sensitivity and specificity.

Keyphrases

fine needle aspiration
high grade
induced apoptosis
ultrasound guided
small cell lung cancer
squamous cell carcinoma
cell cycle arrest
single cell
cell death
oxidative stress
endoplasmic reticulum stress